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KMID : 0359919940130020327
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Korean Journal of Nephrology
1994 Volume.13 No. 2 p.327 ~ p.332
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A Case of Idiopathic Rapidly Progressive Glomerulonephritis with Pulmonary and Cerebral Hemorrhage
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장미경
이영호/김난희/차대룡/권영주/조원용/김형규/원남희
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Abstract
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Rapidly progressive glomerulonephritis (RPGN) is one of the most calamitous renal disease which consists clinically of sudden and relentless deterioration in renal function within weeks to months and is associated with the pathologic finding of
extensive extracapilary prolliferation, ie, crescentic glomerulonephritis (CGN). RPGN is associated with multisystem disordder such as dWegener's granulomatosis and Henoch-Schonlein purpura, or with infectious disorder as bacterial endocarditis.
In
addition, it may occur in patients without a definite diagnosis of a systemic illness. However classifying the latte4r patients as vasculitis is hampered by the lack of tissfue confirmation from the representative vasculitis lesion.
Recently suggested that autoantibodies against myeloid lysosomal enzymes ie, P-ANCA were closely associatd with vasculitis related and idiopathic crescentic glomerulonephritis.
On this paper we are reporting a case of rapidly progressive glomerulonephtitis with pulomonary and cerebral hemorrhage in 68 year old man and this finding support that the pauci-immune idiopathic crescentic glomerulonephritis is related to the
spectrfum of vasculitides.
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